NACC1 (nucleus accumbens associated 1, BEN and BTB (POZ) domain containing)

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Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification

Nucleus accumbens associated 1 (NACC1) is a cancer-associated BTB/POZ (pox virus and zinc finger/bric-a-brac tramtrack broad complex) gene, and is involved in several cellular functions in neurons, cancer and stem cells. Some of the BTB/POZ proteins associated with cancer biology are SUMOylated, which appears to play an important role in transcription regulation. We show that NACC1 is SUMOylate...

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Drosophila Mrityu encodes a BTB/POZ domain-containing protein and is expressed dynamically during development.

We report the identification and characterization of expression of a new gene in Drosophila, which we have named Mrityu (Mri). Mri was initially isolated in a microarray screen to identify molecules regulated by the transcription factor klumpfuss during retinal apoptosis. The amino acid sequence of Mri contains a BTB/POZ domain with homologues across the animal kingdom. Mri transcripts are pres...

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Backbone resonance assignment of the BCL6-BTB/POZ domain

BCL6 is a transcriptional repressor. Two domains of the protein, the N-terminal BTB-POZ domain and the RD2 domain are responsible for recruitment of co-repressor molecules and histone deacetylases. The BTB-POZ domain is found in a large and diverse range of proteins that play important roles in development, homeostasis and neoplasia. Crystal structures of several BTB-POZ domains, including BCL6...

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Flexible DNA binding of the BTB/POZ-domain protein FBI-1.

POZ-domain transcription factors are characterized by the presence of a protein-protein interaction domain called the POZ or BTB domain at their N terminus and zinc fingers at their C terminus. Despite the large number of POZ-domain transcription factors that have been identified to date and the significant insights that have been gained into their cellular functions, relatively little is known...

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Overexpression, purification, characterization, and crystallization of the BTB/POZ domain from the PLZF oncoprotein.

The BTB/POZ domain defines a conserved region of about 120 residues and has been found in over 40 proteins to date. It is located predominantly at the N terminus of Zn-finger DNA-binding proteins, where it may function as a repression domain, and less frequently in actin-binding and poxvirus-encoded proteins, where it may function as a protein-protein interaction interface. A prototypic human B...

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ژورنال

عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology

سال: 2012

ISSN: 1768-3262

DOI: 10.4267/2042/48148