NACC1 (nucleus accumbens associated 1, BEN and BTB (POZ) domain containing)
نویسندگان
چکیده
منابع مشابه
Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification
Nucleus accumbens associated 1 (NACC1) is a cancer-associated BTB/POZ (pox virus and zinc finger/bric-a-brac tramtrack broad complex) gene, and is involved in several cellular functions in neurons, cancer and stem cells. Some of the BTB/POZ proteins associated with cancer biology are SUMOylated, which appears to play an important role in transcription regulation. We show that NACC1 is SUMOylate...
متن کاملDrosophila Mrityu encodes a BTB/POZ domain-containing protein and is expressed dynamically during development.
We report the identification and characterization of expression of a new gene in Drosophila, which we have named Mrityu (Mri). Mri was initially isolated in a microarray screen to identify molecules regulated by the transcription factor klumpfuss during retinal apoptosis. The amino acid sequence of Mri contains a BTB/POZ domain with homologues across the animal kingdom. Mri transcripts are pres...
متن کاملBackbone resonance assignment of the BCL6-BTB/POZ domain
BCL6 is a transcriptional repressor. Two domains of the protein, the N-terminal BTB-POZ domain and the RD2 domain are responsible for recruitment of co-repressor molecules and histone deacetylases. The BTB-POZ domain is found in a large and diverse range of proteins that play important roles in development, homeostasis and neoplasia. Crystal structures of several BTB-POZ domains, including BCL6...
متن کاملFlexible DNA binding of the BTB/POZ-domain protein FBI-1.
POZ-domain transcription factors are characterized by the presence of a protein-protein interaction domain called the POZ or BTB domain at their N terminus and zinc fingers at their C terminus. Despite the large number of POZ-domain transcription factors that have been identified to date and the significant insights that have been gained into their cellular functions, relatively little is known...
متن کاملOverexpression, purification, characterization, and crystallization of the BTB/POZ domain from the PLZF oncoprotein.
The BTB/POZ domain defines a conserved region of about 120 residues and has been found in over 40 proteins to date. It is located predominantly at the N terminus of Zn-finger DNA-binding proteins, where it may function as a repression domain, and less frequently in actin-binding and poxvirus-encoded proteins, where it may function as a protein-protein interaction interface. A prototypic human B...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/48148